Figure 4.

IL-10-modified ADMSC inhibited the synthesis of extracellular matrix in HSFs. HSFs were cultured alone, or added 1 μg/L IL-10 in the medium, or cocultured with ADMSC/IL-10-ADMSC for 3 days. (a–e) We harvested the HSFs to detect the expression of collagen-I, collagen-III, α-SMA, and FN protein; (f) we collected the cell culture medium to determine the concentration of 4-hydroxyproline. Data was expressed as (SD ± mean), and each analysis was repeated at least 3 times independently; P value was calculated by one-way ANOVA; ^∗∗∗ was P < 0.001 vs. ADMSC group; ^### was P < 0.001 vs. control group.