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. 2022 Jun 23;9(3):ENEURO.0181-22.2022. doi: 10.1523/ENEURO.0181-22.2022

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Copyright © 2022 Hernandez et al.

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Figure 5. — Effects of high-frequency stimulation on fEPSP peak amplitudes. A, Representative traces for each group. B, The fEPSP peak amplitude differences between baseline and post-HFS within each age group. There is a significant genotype × time interaction within the young adult group, whereas there are no genotypic differences within the other age groups. There was an overall main effect of age such that young adults had larger magnitude post-HFS peak amplitudes relative to middle-aged and older-aged groups. C, STP and LTP relative to BL within the young adult WT rats. There was significant STP and LTP relative to BL. D, STP and LTP relative to BL within the young adult TgAD rats. There was significant STP and LTP relative to BL. E, STP and LTP relative to BL within the middle-aged WT rats. There was significant STP but not LTP relative to BL. F, STP and LTP relative to BL within the middle-aged TgAD rats. While there was not significant STP, there was significant LTP relative to BL. G, STP and LTP relative to BL within the older-aged WT rats. There was no STP or LTP relative to BL. H, STP and LTP relative to BL within the older-aged TgAD rats. There was no STP or LTP relative to BL. Data are plotted as the mean and SEM and fEPSP peak amplitudes as percentage of baseline. *p < 0.05, **p < 0.01, ***p < 0.001 for paired-samples t tests; ×××p < 0.001 for genotype × time interactions. Dotted black line represents mean of YA-WT at 30 min post-HFS. Dashed black line represents baseline.