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. 2022 May 9;39(7):3131–3145. doi: 10.1007/s12325-022-02148-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — a SELENA-SLEDAI and PGA scores by disease activity patterns over the observation period and b organ manifestations by SELENA-SLEDAI domains over the observation period by disease activity pattern. ***p < 0.001 MSK-CA vs MSK-RR; **p < 0.01 MSK-CA vs MSK-RR; *p < 0.05 MSK-CA vs MSK-RR; ^†††p < 0.001 MSK-CA vs MSK-LQ; ^††p < 0.01 MSK-CA vs MSK-LQ; ^†p < 0.05 MSK-CA vs MSK-LQ; ^###p < 0.001 MSK-RR vs MSK-LQ; ^##p < 0.001 MSK-RR vs MSK-LQ; and ^#p < 0.05 MSK-RR vs MSK-LQ. CA chronically active, LQ long quiescence, MSK musculoskeletal, PGA Physician Global Assessment, RR relapsing–remitting, SELENA SLEDAI Safety of Estrogens in Lupus National Assessment Systemic Lupus Erythematosus Disease Activity Index