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. 2022 Jun 28;18(7):45. doi: 10.1007/s11306-022-01905-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Extrinsic and intrinsic factors contribute to distinct metabolic signatures in T2D among ethnic groups. External elements such as diet and lifestyle modifications influence the metabolome in the T2D. Heterogeneity in the prevalence of T2D across various ethnic groups are also due to socio-economic status and the availability of health infrastructure. Besides, intrinsic factors such as genetic makeup and epigenetic modifications also influence biomolecule metabolism leading to diversity in the metabolite patterns among various ethnic groups in the context of T2D.