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. 2022 Jun 28;13:3571. doi: 10.1038/s41467-022-31169-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Spike-specific IgG1 and Fc-receptor (FcR) binding were measured by Luminex. The dot plots show the titer for pregnant individuals who received Ad26.COV2.S (red), mRNA-1273 (yellow) or BNT162b2 (blue). The black diamond represents the group median. Significance was determined by Kruskal–Wallis test followed by posthoc Benjamini–Hochberg correction adjustment, *p < 0.05, **p < 0.01, ***p < 0.001. The exact p-values stated in the following order for all subpanels: mRNA-1273 vs Ad26.COV2.S, then BNT162b2 vs Ad26COV2.S. IgG1: p = 0.00035; p = 0.00048. FcR2a: p = 0.00018; p = 0.00019. FcR2b: p = 0.00018; p = 0.00019. FcR3a: p = 0.00018; p = 0.00019. B The dot plots show the Spike-specific antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil phagocytosis (ADNP), antibody-dependent complement deposition (ADCD), and antibody-dependent NK cell degranulation, as measured by % CD107a + NK cells, in maternal samples. The black diamond represents the group median. Significance was determined by Kruskal–Wallis test followed by posthoc Benjamini–Hochberg correction adjustment, *p < 0.05, **p < 0.01, ***p < 0.001. The exact p-values stated in the following order for all subpanels: mRNA-1273 vs Ad26.COV2.S, then BNT162b2 vs Ad26COV2.S. ADCP: p = 0.00018 for both; ADNP: p = 0.0001 both; ADCD: p = 0.0001 both; % CD107a+: p = 0.00019 for both. C The dot plots show the S1- (top) or S2- (bottom) specific IgG1 or FcR-binding in maternal samples. Significance was determined by Kruskal–Wallis test followed by posthoc Benjamini–Hochberg correction adjustment, *p < 0.05, **p < 0.01, ***p < 0.001. The black diamond represents the group median. The exact p-values stated in the following order for all subpanels: mRNA-1273 vs Ad26.COV2.S, then BNT162b2 vs Ad26COV2.S. FcR2a S2: p = 0.00018, p = 0.0006. FcR3a S2: p = 0.000045, p = 0.000036. D A partial-least squares discriminant model (PLSDA) was built using least absolute shrinkage and selection operator (LASSO)-selected SARS-CoV-2 specific antibody features in maternal samples, using vaccine type as the outcome variable. Each dot represents a sample, with the color representing the vaccine type. The ellipses represent the 95% confidence interval for the vaccine. E The barplot shows the latent variable (LV) 1 for the LASSO-selected features for the PLSDA in (D). Features with a positive loading along LV1 are enriched in mothers who received an mRNA vaccination, and features with a negative loading are enriched in mothers who received Ad26.COV2.S. Nearly all features are enriched in mRNA vaccine recipients. Source data are presented in Source Data File 1.