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. 2022 Jun 28;13:3571. doi: 10.1038/s41467-022-31169-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The dot plots show the Spike-specific IgG titer in maternal (M) or cord (C) plasma. Lines connect paired dyads. The color indicates the trimester of vaccination, first (orange), second (blue) or third (pink). Significance was determined by a Wilcoxon signed-rank test (2-sided), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Exact p-values presented first trimester: p < 0.0001 (GraphPad Prism does not provide a more exact p-value for this comparison), second trimester: p < 0.0001. B The dot plot shows the transfer ratio (cord titer/maternal titer) of Spike-specific IgG to the cord. Color indicates the trimester of vaccination. Significance was determined by Kruskal–Wallis test. ****p < 0.0001. The horizontal line represents the group median. Exact p-value 1st vs 3rd TR: p < 0.0001 (GraphPad does not provide any more exact p-value); 2nd vs 3rd p < 0.0001. C The dot plot shows the Spike-specific IgG titer in cord blood by trimester that the mother received COVID-19 vaccination. Significance was determined by a one-way ANOVA followed by correction for multiple comparisons, *p < 0.05. The horizontal line represents the group median. Exact p-value 1st vs 2nd p = 0.017. D The dot plots show the IgG Spike titer in maternal plasma post-boost (~2–6 weeks after the second dose of mRNA vaccine or after a single dose of Ad26.COV2.S vaccine) and at delivery following vaccination in the first (orange) and second (blue) trimester. Lines connect matched samples. Significance was determined by a Wilcoxon signed-rank test (2-sided), *p < 0.05, **p < 0.01. Exact p-value 1st p = 0.016. Exact p-value 2nd p = 0.002. E The dot plot shows the ratio of the IgG Spike titer delivery/post-boost following vaccination in the first (orange) and second (blue) trimesters. Significance was determined by a two-tailed Mann–Whitney test, **p < 0.01. The horizontal line represents the group median. Exact p-value 1st vs 2nd p = 0.0085. Source data are presented in Source Data File 2.