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. 2022 Jun 28;7:70. doi: 10.1038/s41541-022-00496-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — C57BL/6 mice (n = 5/group) were administered the test vaccine at 1/10, 1/40, 1/160, 1/640 doses of O PA2 or O PA2-C3d or A22 or A22-C3d antigen for cattle or pig use, ISA 206 (oil-based emulsion, 50%, w/w), 10% Al(OH)₃, and 15 µg Quil-A. A negative control (NC) group was injected with the same volume of PBS. The test vaccines were injected intramuscularly into mice that were later challenged with FMDV type O (100 LD₅₀ O/VET/2013) or FMDV type A (100 LD₅₀ A/Malay/97) at 7 dpv. The survival rates and body weights were monitored for 7 dpc. (a–i) Experimental strategy (a); survival rates post-challenge with O/VET/2013 (b, d) or A/Malay/97 (f, h); changes in body weight post-challenge with O/VET/2013 (c, e) or A/Malay/97 (g, i). The data represent the mean ± SEM of triplicate measurements (n = 5/group).