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. 2022 Jun 28;12:10890. doi: 10.1038/s41598-022-13222-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plot of hazard ratios (dots) and 95% confidence intervals (lines) for PRSxE interactions obtained from Cox regressions. Hazard ratios were adjusted for other covariates, including polygenic risk. Statistically significant results (FDR < 0.05) represented by filled circles. x-axis truncated at 2. For continuous variables, hazard ratios are given per standard deviation of the variable per standard deviation of PRS. For binary variables, hazard ratios are given per standard deviation of PRS. Results for 24-h dietary variables are shown in Supplemental Fig. 4. Results for hormone replacement therapy not displayed because they did not meet the proportional hazards assumption.