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. 2022 Jun 28;12:10890. doi: 10.1038/s41598-022-13222-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier curves for variables with statistically significant PRSxE interactions (FDR < 0.05 in Cox regressions conditional on polygenic risk and other covariates), with IBD diagnosis as the event. “Never” indicates participants never exposed to variable, “previous” refers to participants who started and subsequently stopped exposure, “lowPRS” refers to polygenic risk below median, “highPRS” refers to polygenic risk above median. Curves of current users are omitted to emphasize the interactive effect. OCT = oral contraceptive therapy.