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. 2022 Jun 28;8:61. doi: 10.1038/s41421-022-00407-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Volcano plot of DEGs between LP and EP. ECM-related genes such as thrombospondin, periostin, and collagens are shown on plot. Genes with adjusted P-value < 0.1 were colored by orange (log-fold change > 1) or blue (log-fold change < –1), whereas ≥ 0.1 were colored as gray. b Bar plot of gene ontology terms enriched with DE genes of LP (log-fold change > 0). c Venn diagram of highly variable gene sets between EP and LP. Highly variable genes between two populations were selected. Genes with raw counts > 3 were kept as set in the diagram.