Table 2.
IH staining grades and patterns in HBV-HIV Co-infected North American Adults at study entry and approximately 3–4 years later (N=56).
| Baseline n (%) | Follow-up n (%) | Change P valuea | |
|---|---|---|---|
| HBcAg staining grade, n (%) | 0.058 | ||
| A (No positive hepatocytes) | 21 (37.5) | 35 (62.5) | |
| B (Less than 10% positive) | 28 (50.0) | 17 (30.4) | |
| C (≥10% positive) | 7 (12.5) | 4 (7.1) | |
| HBcAg staining pattern | 0.02 | ||
| No positive hepatocytes | 21 (37.5) | 35 (62.5) | |
| Only/predominately nuclear | 20 (35.7) | 13 (23.2) | |
| Only/predominately cytoplasmic | 15 (26.8) | 8 (14.3) | |
| HBsAg staining grade, n (%) | 0.63 | ||
| A (No positive hepatocytes) | 13 (23.2) | 16 (28.6) | |
| B (Less than 10% positive) | 33 (58.9) | 32 (57.1) | |
| C (≥10% positive) | 10 (17.9) | 8 (14.3) | |
| HBsAg staining: Granular cytoplasmic- contiguous regions pattern | 0.04 | ||
| No | 36 (64.3) | 45 (80.4) | |
| Yes | 20 (35.7) | 11 (19.6) | |
| HBsAg staining pattern: Granular cytoplasmic-scattered hepatocytes b | 0.44 | ||
| No | 16 (28.6) | 19 (33.9) | |
| Yes | 40 (71.4) | 37 (66.1) | |
| HBsAg staining pattern: Inclusion-like b | 0.03 | ||
| No | 29 (51.8) | 40 (71.4) | |
| Yes | 27 (48.2) | 16 (28.6) | |
| HBsAg staining pattern: Membranous b | 0.21 | ||
| No | 45 (80.4) | 49 (87.5) | |
| Yes | 11 (19.6) | 7 (12.5) |
a
Changes were tested with mixed-effects models (binomial, ordinal logistic or multinomial, as appropriate) with a repeated outcome, time (i.e., days since first biopsy) as a continuous fixed effect, and random intercept. Median (IQR; range) of time between biopsies was: 3.6 (3.0–3.7; 2.6–4.1) years.