TABLE 3.

Subgroup analysis for detecting glaucomatous optic neuropathy in groups stratified by yes/no myopic features.

	AUROC (95% CI)	*p-value	Sensitivity, % (95% CI)	Specificity, % (95% CI)	Accuracy, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)
Internal validation
yes MF	0.938 (0.913–0.962)	0.65	85.4 (77.6–93.7)	90.4 (79.8–95.6)	87.2 (82.8–90.6)	94.0 (89.3–97.2)	77.3 (69.9–87.6)
no MF	0.952 (0.896–1)	\	94.4 (83.3–100)	95.0 (87.9–100)	94.1 (88.9–97.8)	86.8 (73.9–100)	97.8 (94.1–100)
External testing 1
yes MF	0.884 (0.849–0.918)	0.67	78.1 (67.0–85.6)	88.8 (80.8–96.8)	81.8 (76.8–86.2)	92.1 (87.8–97.2)	70.1 (62.6–77.6)
no MF	0.896 (0.851–0.941)	\	83.5 (68.4–93.7)	83.3 (72.2–94.4)	83.4 (77.6–88.3)	75.8 (66.4–89.6)	88.8 (82.4–94.9)
External testing 2
yes MF	0.926 (0.879–0.972)	0.47	87.8 (75.7–97.3)	90.2 (78.7–98.4)	88.9 (83.7–93.3)	91.8 (84.3–98.5)	86.6 (76.3–96.2)
no MF	0.900 (0.849–0.951)	\	79.7 (62.3–95.7)	90.5 (68.3–100)	83.3 (78.0–88.6)	90.0 (75.9–100)	80.3 (70.0–94.8)
External testing 3
yes MF	0.883 (0.847–0.919)	< 0.001	74.7 (64.9–86.8)	90.1 (76.2–97.0)	78.6 (72.3–85.4)	95.5 (91.2–98.6)	54.8 (47.7–67.5)
no MF	0.965 (0.937–0.992)	\	90.9 (78.8–98.5)	94.2 (82.7–100)	91.5 (86.4–95.8)	94.7 (87.5–100)	89.3 (78.1–98.0)
External testing 4
yes MF	0.941 (0.916–0.966)	0.95	85.7 (79.9–91.2)	94.7 (87.7–100)	86.7 (81.7–91.2)	99.3 (98.3–100)	44.4 (36.3–55.4)
no MF	0.940 (0.918–0.962)	\	84.7 (77.2–90.9)	91.8 (85.4–97.5)	87.5 (84.0–90.7)	94.1 (90.2–97.9)	79.8 (73.1–86.4)
External testing 5
yes MF	0.923 (0.897–0.949)	0.93	87.8 (78.1–92.3)	88.3 (81.3–95.3)	87.6 (83.4–90.6)	92.5 (88.9–96.6)	80.8 (71.5–87.1)
no MF	0.925 (0.902–0.947)	\	78.8 (73.0–84.2)	95.5 (92.6–97.6)	89.2 (86.7–91.5)	91.2 (86.0–95.2)	88.4 (85.8–91.0)

*Z-test was used to compare the AUROC values between yes/no myopic features groups. p-values in bold were AUROC values with significant difference.