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. 2022 Jan 20;10(3):531–542. doi: 10.14218/JCTH.2021.00344

Fig. 1. Illustration of potential pathogenic factors of PSC-IBD.

Fig. 1

AE2, Cl−/HCO3− anion exchanger; TLR, Toll-like receptor; CFTR, cystic fibrosis transmembrane conductance regulator; TGR5, G protein-coupled bile acid receptor 1; VAP-1, vascular adhesion protein 1; MadCAM-1, Mucosal addressin cell adhesion molecule; ASCAs, Anti-Saccharomyces cerevisiae antibodies; Anti-BEC, anti- biliary epithelial cell antibody; PR3-ANCA, Proteinase 3 anti-neutrophil cytoplasmic antibody; FXR, nuclear farnesoid X receptor; ASBT, apical sodium-bile acid transporter; HLA, human leukocyte antigen.