Table 1.

Characteristics of metagenomic datasets used in this study.

Study	No. of controls	No. of CRC	Country	Reference
Zeller	93	91	France/Germany	(Zeller et al., 2014)
Yu	54	74	China	(Yu et al., 2017)
Feng	63	46	Austria	(Feng et al., 2015)
Vogtmann	52	52	USA	(Vogtmann et al., 2016)
Thomas	52	61	Italy	(Thomas et al., 2019)
Yachida	40	40	Japan	(Yachida et al., 2019)
Yang	95	98	China	(Yang et al., 2020)
Total	449	462