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. 2022 Jun 15;13:907209. doi: 10.3389/fphar.2022.907209

FIGURE 2.

FIGURE 2

Urolithin A (UroA) attenuates renal oxidative stress in fructose-induced urate nephropathic mice. (A) ROS level in renal tissues measured by 2′, 7′-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining. (B–D) MDA content and T-SOD/GSH-Px antioxidant enzyme activity in kidney tissues from the wild-type (WT) or fructose-fed mice with intragastric administration of either vehicle or UroA, respectively. Mean ± S.D., n = 8. ## p < 0.01, ### p < 0.001 versus the WT group; * p < 0.05, ** p < 0.01, *** p < 0.001 versus the fructose group. UroA-L and UroA-H represent intragastric administration of urolithin A at low (50 mg/kg/day) and high (100 mg/kg/day) doses, respectively. Prot. is the abbreviation of protein.