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. 2022 Jun 15;10:902298. doi: 10.3389/fcell.2022.902298

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Copyright © 2022 Yang, Shan, Zhao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of metabolism-associated DNA methylation patterns. (A) Flowchart of the research. (B) Relative changes in the area under the CDF curve when k ranges from 2 to 10. (C) Consensus matrix heatmap of the three distinct subgroups in the TCGA cohort. (D) Heatmap of metabolism-associated CpGs in the three subgroups of the TCGA cohort. (E,F) Kaplan-Meier analysis of the three subgroups in the TCGA cohort and the GEO cohort. (G) PCA of metabolism-associated CpGs to demonstrate the three subgroups in the TCGA and GEO cohorts. CDF, cumulative distribution function; PCA, principal component analysis.