TABLE 1.
Univariate and multivariate Cox regression analysis of risk score and other clinical features in the TCGA/CGGA/GEO cohorts.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| TCGA cohort | ||||
| Risk score | 14.595 (9.487–22.454) | 3.66E-30 | 10.829 (5.154–22.754) | 3.21E-10 |
| Age | 3.119 (2.096–4.640) | 5.19E-09 | 2.235 (1.431–3.490) | 4.04E-04 |
| IDH mutation | 6.307 (4.325–9.198) | 4.10E-18 | 0.657 (0.326–1.323) | 2.39E-01 |
| Grade | 3.312 (2.227–4.926) | 4.36E-10 | 2.183 (1.415–3.367) | 4.15E-04 |
| 1p/19q codel | 0.400 (0.250–0.641) | 2.95E-05 | 0.615 (0.364–1.040) | 6.97E-02 |
| GEO cohort | ||||
| Risk score | 3.689 (2.145–6.344) | 4.37E-05 | 6.620 (1.102–39.775) | 3.88E-02 |
| Age | 1.101 (0.743–1.632) | 6.30E-01 | 1.028 (0.692–1.527) | 8.90E-01 |
| IDH1 mutation | 0.254 (0.166–0.389) | 1.49E-08 | 0.471 (0.227–0.976) | 4.28E-02 |
| Grade | 1.961 (1.288–2.986) | 2.57E-03 | 1.049 (0.627–1.754) | 8.56E-01 |
| CGGA cohort | ||||
| Risk Score | 5.296 (3.523–7.961) | 1.26E-13 | 3.641 (1.977–6.705) | 3.36E-05 |
| Age | 1.154 (0.776–1.718) | 4.78E-01 | 1.492 (0.947–2.350) | 8.42E-02 |
| IDH mutation | 3.168 (2.082–4.820) | 3.30E-07 | 0.831 (0.653–2.218) | 5.53E-01 |
| Grade | 2.506 (1.625–3.863) | 1.38E-05 | 3.125 (1.886–5.178) | 9.70E-06 |
| 1p/19q codel | 0.202 (0.107–0.381) | 3.96E-09 | 0.321 (0.159–0.650) | 1.57E-03 |
P-values marked in bold were considered significant statistically(p < 0.05).