Table 2.

Synergism due to pharmacodynamics interaction

Drug A & its mechanism of action	Drug B & its mechanism of action	Reported effects	Possible mechanism of action
Cycloserine (inhibits bacterial cell-wall synthesis)	Epigallocatechin gallate (interruption of bacterial cell wall integrity)	Destruction of bacteria cell wall due to the synergistic antibacterial action	The presence of both the component together complements each other. Epigallocatechin disrupts the integrity of bacterial cell wall and cycloserine act as an inhibitor for cell wall synthesis, which hampers the restoration of the cell wall
Ampicillin (interrupt bacterial cell-wall synthesis by blocking PBP2A (peptidoglycan transpeptidase)	Daptomycin (break down of bacterial cell membrane structure)	Strong synergistic antibacterial action	Membrane disruption due to daptomycin, perhaps supported by the presence of ampicillin
Artemisinin (disrupts parasite mitochondrial function, modulates host immune function)	Curcumin (generates ROs and produce cytotoxicity for malaria parasites)	Synergic/additiveantimalarial activities	They act at different sites in a non-interfering manner
Ampicillin (inhibit bacterial cell-wall synthesis by blocking PBP2A	Imipenem inhibits bacterial cell-wall synthesis by blocking PBP1A, 1B	Synergic/additiveantibacterial effect	Both act at the same active site. Due to the presence of both at relatively high MICs (minimum inhibitory concentration), may make it responsible for the better antibacterial effect