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. 2022 Jan 31;7(3):222–236. doi: 10.1136/svn-2021-001308

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Cerebral venous circulation disturbance increased infarction volume, and NBP could reduce infarct area after 3 days of treatment. (A) Infarction volume was evaluated by TTC staining 24 hours and 72 hours postoperation in groups of MCAO, EJVO+MCAO and EJVO+MCAO+ NBP. (B) Quantification of infarction volume at 24 hours after operation. (C) Quantification of infarction volume at 72 hours after operation. Data are presented as mean±SD; n=5 per group. *P＜0.05, EJVO+MCAO vs MCAO; #P<0.05, EJVO+MCAO + NBP vs EJVO+MCAO. Scale bar=5 mm. EJVO, external jugular vein occlusion; MACO, middle cerebral artery occlusion; NBP, Dl-3-n-butylphthalide; TTC, 2, 3, 5-triphenyltetrazolium chloride.