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. 2022 Jan 31;7(3):222–236. doi: 10.1136/svn-2021-001308

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Cerebral venous circulation disturbance delayed recovery of CBF after MCAO, and NBP promoted CBF restoration. (A) CBF maps were generated from ASL and EJVO +MCAO group showed a lower CBF than MCAO group. NBP treatment could accelerate CBF recovery after rats underwent MCAO operation plus with EJVO. (B) Quantitative analysis showing changes of CBF in infarct area from first to 14th day. data are presented as mean±SD; n=5 per group. **P＜0.01, EJVO +MCAO vs Sham; ##p＜0.01, MCAO vs sham; §§p＜0.01, EJVO +MCAO + NBP vs EJVO +MCAO. CBF, cerebral blood flow; EJVO, external jugular vein occlusion; MACO, middle cerebral artery occlusion; NBP, Dl-3-n-butylphthalide.