. 2022 Jun 15;9:823756. doi: 10.3389/fnut.2022.823756

TABLE 4.

Blood biochemistry profile.

	Groups

Parameters	ND	HFD	HFDh	HFDo
Triglycerides (mg/dl)	101.67 ± 9.89^a	80.75 ± 5.31^ab	72.38 ± 2.22^b	65.29 ± 4.89^b
Total cholesterol (mg/dl)	124.5 ± 5.94^c	197.38 ± 15.02^b	229 ± 11.15^ab	245 ± 8.79^a
HDL cholesterol (mg/dl)	99.77 ± 3.97^b	147.64 ± 10.38^a	163.79 ± 6.37^a	175.84 ± 5.87^a
FFA (nmol/μl)	0.29 ± 0.01^ab	0.24 ± 0.01^b	0.30 ± 0.02^a	0.27 ± 0.01^ab
AST (IU/L)	52.6 ± 5.18^c	88.71 ± 10.86^bc	101 ± 8.79^ab	134.86 ± 11.17^a
ALT (IU/L)	31.2 ± 7.56^b	112.13 ± 19.44^a	114.25 ± 13.52^a	158.38 ± 11.73^a
ALP (IU/L)	69.67 ± 4.18	70.88 ± 7.07	76.88 ± 4.51	76.25 ± 4.5
Insulin (mmol/l)	6.97 ± 0.65^b	10.51 ± 0.34^b	14.52 ± 0.99^a	14.92 ± 1.29^a
HOMA-IR index	0.51 ± 0.07^c	4.04 ± 0.68^c	15.74 ± 1.61^a	9.42 ± 1.65^b

The effect of diets on lipid profiles, free fatty acid (FFA) blood levels, liver enzymes, insulin level, and HOMA-IR Index. Mice consumed either a normal diet (ND), a high-fat diet (HFD), a high-fat diet plus 4% (w/w) of HN (HFDh) or HO (HFDo) peanuts for 18 weeks. At the end of the experiment, plasma triglycerides, cholesterol, HDL-cholesterol (high-density lipoprotein cholesterol), alkaline phosphatase (AST), glutamic-pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (ALP), FFA levels, and insulin levels were measured in the plasma (n = 8). HOMA-IR index was calculated by using the formula: [Fasting insulin concentration (microU/ml) × Glucose concentration (mg/dl)/405]. A Tukey–Kramer HSD post hoc statistical test was performed. The value presented are mean ± SE (n = 8). Different letters indicate statistical variance at a significant level of p < 0.05.