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. 2022 Jun 15;13:881099. doi: 10.3389/fmicb.2022.881099

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Copyright © 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative metabolomics analysis of changes in the intestine metabolites in the starvation and control groups. (A) Variation of intestinal metabolite structure represented by PCA of multivariate statistical analysis (MVA). (B) Venn diagram showing the metabolite profile between starvation and control groups in positive ion mode (PIM) and (C) negative ion mode (NIM). (D) Kruskal–wallis test was used to screen the different metabolites in the three groups (The names of the annotated bacteria displayed the top 63). (E) The correlation among 30 genera and 30 metabolites is shown using a heatmap. Color intensity represents the magnitude of the correlation. Red, positive correlations; blue, negative correlations.