FIGURE 2.

Currently available animal models of PH‐LHD. At present, PH‐LHD animal models are established by (1) pressure overload‐induced LV failure including aortic banding (AoB), transverse aortic constriction (TAC), pulmonary vein banding (PVB), and left atrium stenosis (LAS); (2) ischemic heart failure via ligation of left coronary artery; and (3) metabolic disturbance induced by high‐fat diet (HFD) alone or with pressure overload‐induced LV failure, or the combination of olanzapine and pressure overload‐induced LV failure, or by genetic predisposition of cardiometabolic syndrome and SU5416. Created with BioRender.com