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. 2022 Jun 29;377:e068743. doi: 10.1136/bmj-2021-068743

Table 1.

Summary of included studies, in chronological order by setting: quarantine hotels, restaurants, buses, and apartment blocks

Reference (quality rating) Transmission event, setting, date No of cases Outcome and exposure assessment Potential for other transmission routes Potential for airborne transmission >2 m* Modifying factors
Li et al,34 Lu et al,49 Zhang et al50 (medium) Restaurant, China, January 2020 Ten confirmed cases from three tables No genomic sequencing. Epidemiological data, video recording, on-site visit, design of air conditioning and ventilation system, experiments to assess airflow and ventilation rates Close contact or fomite transmission unlikely (except for cases in same household). Transmission from outside event possible for some cases Possible airborne transmission between primary case and at least two secondary cases; up to 1.4 m (53 min) and 4.6 m (75 min) from primary case Insufficient air replacement. Directional air flow through air circulation units
Shen et al36 (medium) Buses, China, January 2020 Twenty four confirmed cases No genomic sequencing. Questionnaires and interviews, contact tracing data, bus design, and ventilation system Close contact, fomite transmission, or transmission from outside event possible for some cases Possible airborne transmission >2 m from primary case (50 min) Insufficient air replacement. Directional air flow from central heating system
Luo et al,37 Ou et al51 (low) Buses, China, January 2020 Nine confirmed cases No genomic sequencing. Epidemiological data, information on loading and unloading stops of all passengers, and seating positions, ventilation systems, tracer gas experiments Close contact unlikely. Fomite transmission or transmission from outside event possible for some cases Possible airborne transmission >2 m for some cases (1 hour to 2.5 hours) Insufficient air replacement. Directional air flow due to exhaust system
Lin et al38 (low) Apartment block, China, January 2020 Nine confirmed cases from three households No whole genome sequencing (partial S gene only). Interviews with cases, CCTV of lift, tracer gas and wind speed experiments Close contact or fomite transmission unlikely (except for cases in same household); transmission from outside event possible for some cases Possible airborne transmission between cases in one flat to two different flats (up to 10 floors from flat of primary case) Insufficient air replacement. Directional air flow through drainage and exhaust system
Kwon et al35 (high) Restaurant, South Korea, June 2020 Three confirmed cases Genomic sequencing. Contact tracing, interviews, credit card records, video recording, mobile phone location data, on-site visits, air flow measurement, environmental sampling Close contact, fomite transmission, or transmission from outside event unlikely Possible airborne transmission between cases seated 4.8 m (21 min) and 6.5 m (5 min) from the primary case Insufficient air replacement. Directional air flow through air circulation units
Hwang et al39 (low) Apartment block, South Korea, August 2020 Ten confirmed cases from seven households No genomic sequencing. Epidemiological data, surface sampling, building assessment Close contact or fomite transmission unlikely (except for cases in same household). Transmission from outside event possible Possible airborne transmission through ventilation ducts across floors for some secondary cases Directional air flow through vertical air duct or floor drain. Insufficient air replacement (unclear)
Eichler et al32 (medium) Quarantine hotel, New Zealand, August-September 2020 Nine confirmed cases, with one secondary case considered for long distance transmission Genomic sequencing. Epidemiological data, surveillance video, review of ventilation system in hotel Close contact or fomite transmission unclear. Transmission from outside event unlikely Possible airborne transmission from hotel room of the primary case to doorway or corridor for one secondary case Insufficient air replacement. Directional air flow
Han et al40 (low) Apartment block, South Korea, January 2021 Five secondary cases (three households) considered for long distance transmission Genomic sequencing. Epidemiological data, interviews, mobile phone location tracking, surface sampling Close contact or fomite transmission unlikely (except for cases in same household). Transmission from outside event unlikely Possible airborne transmission through floor drains across three floors for two secondary cases Insufficient air replacement. Directional air flow through vertical floor drain
Fox-Lewis et al33(high) Quarantine hotel, New Zealand, July 2021 Five confirmed cases in two rooms Genomic sequencing. Epidemiological data, surveillance video, review of ventilation system in hotel Close contact, fomite transmission, or transmission from outside of event unlikely Possible airborne transmission from hotel room of primary case to hotel room for at least one secondary case (2.1 m) Insufficient air replacement. Directional air flow

This review’s assessment of likelihood of airborne transmission of SARS-CoV-2 over distances >2 m is based on likelihood of it occurring in some, but not necessarily all, transmission events.

*

Exposure distance and time are stated when known; if not stated they are categorised as not clear or not specified.