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. 2022 Jun 8;10(6):e004495. doi: 10.1136/jitc-2022-004495

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Methylation status of LINE-1 pre-C2D8 (baseline) and post- (C2D8) guadecitabine. (A) methylation of LINE-1 in PBMC and tumor samples. (B) methylation of IL22RA1 in PBMC samples. *p<0.5, ***p<0.001, ****p<0.0001. C2D8, cycle 2 day 8; CD, cluster of differentiation; FOX-P3, forkhead box P3; IL22RA1, interleukin 22 receptor subunit alpha 1; LINE-1, long interspersed element-1; PBMC, peripheral blood mononuclear cell; PD-L1, programmed death ligand 1.