Intravenous in‐line filters for preventing morbidity and mortality in neonates

. 2015 Aug 6;2015(8):CD005248. doi: 10.1002/14651858.CD005248.pub3

Study	Reason for exclusion
Jack 2012	Jack 2012: Single centre, prospective, randomised controlled trial that randomised 807 critically ill children admitted to paediatric intensive care unit either to control (n = 406) or filter group (n = 401), with the latter receiving in‐line filtration The study included subjects less than 18 years of age (mean age 5 to 6 years). The primary endpoint was reduction in the rate of overall complications, which included the occurrence of systemic inflammatory response syndrome, sepsis, organ failure (circulation, lung, liver, kidney) and thrombosis. Secondary objectives were a reduction in the length of stay in the paediatric intensive care unit and overall hospital stay. Duration of mechanical ventilation and mortality were also analysed Analysis demonstrated a significant reduction in the overall complication rate (n = 166 [40.9 %] vs n = 124 [30.9 %]; P = 0.003) for the filter group. In particular, the incidence of systemic inflammatory response syndrome was significantly lower (n = 123 [30.3 %] vs n = 90 [22.4 %]; P = 0.01). Moreover the length of stay in paediatric intensive care unit (3.89 [95 % confidence interval 2.97‐4.82] vs 2.98 [2.33‐3.64]; P = 0.025) and duration of mechanical ventilation (14.0 [5.6‐22.4] vs 11.0 [7.1‐14.9] h; P = 0.028) were significantly reduced.

Study

Reason for exclusion

Jack 2012

Jack 2012: Single centre, prospective, randomised controlled trial that randomised 807 critically ill children admitted to paediatric intensive care unit either to control (n = 406) or filter group (n = 401), with the latter receiving in‐line filtration
The study included subjects less than 18 years of age (mean age 5 to 6 years). The primary endpoint was reduction in the rate of overall complications, which included the occurrence of systemic inflammatory response syndrome, sepsis, organ failure (circulation, lung, liver, kidney) and thrombosis. Secondary objectives were a reduction in the length of stay in the paediatric intensive care unit and overall hospital stay. Duration of mechanical ventilation and mortality were also analysed
Analysis demonstrated a significant reduction in the overall complication rate (n = 166 [40.9 %] vs n = 124 [30.9 %]; P = 0.003) for the filter group. In particular, the incidence of systemic inflammatory response syndrome was significantly lower (n = 123 [30.3 %] vs n = 90 [22.4 %]; P = 0.01). Moreover the length of stay in paediatric intensive care unit (3.89 [95 % confidence interval 2.97‐4.82] vs 2.98 [2.33‐3.64]; P = 0.025) and duration of mechanical ventilation (14.0 [5.6‐22.4] vs 11.0 [7.1‐14.9] h; P = 0.028) were significantly reduced.

IV: intravenous