Comparison 1. Antimicrobial‐impregnated CVC vs. non‐impregnated CVC.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Catheter‐related bloodstream infection	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 0.87]
2 Mortality prior to hospital discharge	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.21, 2.53]
3 Bronchopulmonary dysplasia	1	86	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.45, 1.42]
4 Necrotising enterocolitis	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.04, 4.84]
5 Retinopathy of prematurity	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.12, 1.70]
6 Length of index CVC use	1	86	Mean Difference (IV, Fixed, 95% CI)	2.30 [0.38, 4.22]
7 Length of hospital stay	1	86	Mean Difference (IV, Fixed, 95% CI)	‐13.00 [‐29.41, ‐0.59]