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. 2022 Jun 13;10:860138. doi: 10.3389/fbioe.2022.860138

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Copyright © 2022 Schumacher, Roumans, Rademakers, Joris, Eischen-Loges, van Griensven and LaPointe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxic organoid culture differentially regulates VEGF-A variants. (A). VEGF-189 is significantly upregulated at both time points in the hypoxic culture. (B). VEGF-A165 is significantly upregulated at day 7+18 in the hypoxic culture and (C). VEGF-121 is significantly upregulated at both time points in the hypoxic culture. (D). Angiogenin mRNA is significantly upregulated over time in both the normoxic and hypoxic culture. The data is plotted relative to day 7+18 normoxia (n=3, N=3 with excluded technical failures). *= p ≤ 0.03, ** = p ≤ 0.002, *** = p ≤ 0.0004.