FIG. 4.

Dependence of protein expression by the proton dose rate in normal cells. Panel A: Western blot analyses of proteins related to mitochondrial functions 24 h after 1.5 or 15 Gy proton irradiation delivered at 0.03 Gy/s or 15 Gy delivered at 100 Gy/s. Panels B–J: Quantification of p-Drp-1; PTEN; cytochrome c; cox-IV; LC3A and LC3B; p53; c-myc; PARP; Caspase-3; cleaved-Caspase-3 and Bax, respectively. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. For each protein we performed three independent experiments.