Table 1.
Descriptive statistics for the participants included in this study. Data are number (N) or mean ± standard deviation.
| Full Sample Healthy Older Adults | Follow-up Sample | Baseline only Sample | |
|---|---|---|---|
| Participants (Ntotal) | 230 | 199 | 31 |
| Female (N) | 129 (56%) | 108 (54%) | 21 (67%) |
| Age at baseline (years) | 73.08 ± 6.49 | 73.26 ± 6.42 | 71.98 ± 6.94 |
| Education (years) | 16.68 ± 2.45 | 16.65 ± 2.53 | 16.87 ± 1.91 |
| ADNI-EF at baseline | 1.00 ± 0.85 | 0.99 ± 0.85 | 1.08 ± 0.90 |
| ADNI-EF at follow-up | ---- | 0.96 ± 0.89 | ---- |
| ADNI-MEM at baseline | 1.06 ± 0.58 | 1.09 ± 0.60 | 0.88 ± 0.47 |
| ADNI-MEM at follow-up | ---- | 1.22 ± 0.621 | ---- |
| ADAS-13 at baseline | 10.09 ± 4.72 | 9.65 ± 4.57 | 12.93 ± 4.802 |
| ADAS-13 at follow-up | ---- | 9.09 ± 4.76 | ---- |
| CSF Aß42 at baseline (pg/mL) | 1228 ± 445 | 1235 ± 448 | 1187 ± 430 |
| CSF pTau181 at baseline (pg/mL) | 21.55 ± 9.06 | 21.52 ± 9.12 | 21.73 ± 8.81 |
| WML load at baseline | 8.67 ± 0.54 | 8.68 ± 0.56 | 8.61 ± 0.42 |
| Systolic blood pressure | 133.40 ± 19.09 | 133.10 ± 18.90 | 135.29 ± 20.48 |
| Diastolic blood pressure | 74.17 ± 11.12 | 74.07 ± 11.50 | 74.84 ± 8.37 |
| BMI | 27.02 ± 4.70 | 27.00 ± 4.65 | 27.11 ± 5.06 |
Notes: ADNI = Alzheimer’s Disease Neuroimaging Initiative. EF = Executive functioning. MEM = Memory. CSF = Cerebrospinal fluid. BMI = Body mass index. ADAS-13, Alzheimer’s Disease Assessment Scale-13; WMLs, White matter lesions ADNI-EF and ADNI-MEM are composite scores that are z-scored values; ADAS-13 is a raw score; WMLs are log-transformed. 1Follow-up participants had higher memory composites (ADNI-MEM, p <.001) and lower ADAS-13 (p =.045) scores at follow-up than baseline. 2The sample with only baseline measures had marginally significantly higher ADAS-13 scores than the sample with follow-up measures (p <.001, uncorrected).