Table 2.
Regression model outputs.
| Model | ADNI-EF Baseline |
ADNI-EF Follow-up |
ADNI-MEM Baseline |
ADNI-MEM Follow-up |
ADAS-13 Baseline |
ADAS-13 Follow-up |
WML load | Aß42 |
|---|---|---|---|---|---|---|---|---|
| Age |
ß= −0.05, t = −5.63, p <.001* |
ß= −0.01, t = −1.99, p =.049 |
ß= −0.03, t = −4.26, p <.001* |
ß= −0.001, t = −0.19, p =.85 |
ß=0.11, t = 2.04, p =.042 |
ß= −0.001, t = −0.01, p = 0.99 |
ß=0.03, t = 5.03, p <.001* | ß= −6.25, t = −1.29, p =.20 |
| Sex | ß=0.05, t = 0.53, p =.60 |
ß= −0.18, t = −2.22, p =.027 |
ß= −0.26, t = −3.56 p <.001* |
ß= −0.13, t = −2.21, p =.028 |
ß=1.50, t = 2.39, p =.018 | ß= −0.17, t = −0.32, p =.75 |
ß= −0.02, t = −0.23, p =.82 |
ß=54.17, t = 0.89, p =.37 |
| Education | ß=0.06, t = 2.95, p =.003* |
ß=0.07, t = 4.39, p <.001* |
ß=0.04, t = 2.81, p =.005* |
ß= 0.02, t = 1.97, p =.050 |
ß= −0.12, t = −0.99, p =.32 |
ß=0.03, t = 0.29, p =.77 |
---- | ---- |
| WML load | ß= −0.11, t = −1.12, p =.26 |
ß= −0.22, t = −2.84, p =.005* |
ß= −0.12, t = −1.67, p =.096 |
ß= −0.10, t = −1.76, p =.081 |
ß=1.59, t = 2.59, p =.01* |
ß=0.89, t = 1.76, p =.080 | ---- | ---- |
| Aß42 |
ß=0.001, t = 3.58, p <.001* |
ß=0.001, t = 1.05, p =.30 |
ß=0.001, t = 0.30, p =.76 |
ß= 0.001, t = 1.18 p =.24 |
ß= −0.001, t = −0.24, p =.81 |
ß=-0.001, t = 0.09, p =.93 |
ß= −0.001, t = −4.20, p <.001* |
---- |
| pTau | ß=0.005, t = 0.92, p =.35 |
ß= −0.003, t = −0.84, p =.40 | ß= −0.002, t = −0.51, p =.61 |
ß= −0.003, t = −0.94, p =.35 |
ß=0.01, t = 0.29, p =.76 |
ß=0.02, t = 0.72, p =.47 |
ß=0.001, t = 0.32, p =.75 |
ß=1.76, t = 0.51, p =.61 |
| Cognitive score at baseline | ---- |
ß= 0.65, t = 12.38, p <.001* |
---- | ß=0.75, t = 14.28, p <.001* | ---- | ß=0.68 t = 11.66, p <.001* | ---- | ---- |
Notes: Significant results are shown in bold. * Represents results that were significant after false discovery rate correction for multiple comparisons. Abbreviations: ADAS-13, Alzheimer’s Disease Assessment Scale-13; WML, White matter lesion.