Table 3.
Secondary exploratory analysis regression model outputs.
| ADNI-EF Baseline |
ADNI-EF Follow-up |
ADNI-MEM Baseline |
ADNI-MEM Follow-up |
ADAS-13 Baseline |
ADAS-13 Follow-up |
|
|---|---|---|---|---|---|---|
| Frontal | ||||||
| WML load | ß= −0.10, t = −0.88, p =.38 |
ß= −0.19, t = −2.32, p =.02 |
ß= −0.10, t = −1.26, p =.21 |
ß= −0.09, t = −1.50, p =.13 |
ß= 1.05, t = −1.58, p =.12 |
ß=0.92, t = 1.72, p =.09 |
| Aß42 | ß=0.001, t = 3.76, p <.001 |
ß=0.001, t = 1.35, p =.18 |
ß= 0.001, t = 0.50, p =.61 |
ß= 0.001, t = 1.38, p =.17 |
ß= −0.001, t = −0.62, p =.54 |
ß=-0.001, t = −0.04, p =.96 |
| pTau | ß= −0.005, t = −0.93, p =.35 |
ß= −0.003, t = −0.83, p =.40 | ß= −0.002, t = −0.49, p =.62 |
ß= −0.003, t = −0.93, p =.35 |
ß=0.01, t = 0.29, p =.77 |
ß=0.02, t = 0.69, p =.49 |
| Temporal | ||||||
| WML load | ß= −0.009, t = −0.08, p =.93 |
ß= −0.18, t = −2.17, p =.03 |
ß= −0.11, t = −1.47, p =.14 |
ß= −0.08, t = −1.29, p =.20 |
ß= 1.59, t = 2.42, p =.016 |
ß=0.70, t = 1.27, p =.20 |
| Aß42 | ß=0.001, t = 3.92, p <.001 |
ß=0.001, t = 1.18, p = 0.24 |
ß= 0.001, t = 0.39, p =.69 |
ß= 0.001, t = 1.33, p =.19 |
ß= −0.001, t = −0.34, p =.73 |
ß=-0.001, t = −0.06, p =.95 |
| pTau | ß= 0.005, t = 0.90, p =.37 |
ß= −0.004, t = −0.98, p =.33 |
ß= −0.002, t = −0.58, p =.56 |
ß= −0.003, t = −1.02, p =.31 |
ß=0.01, t = 0.41, p =.69 |
ß=0.02, t = 0.81, p =.42 |
| Parietal | ||||||
| WML load | ß= −0.07, t = −1.26, p =.21 |
ß= −0.15, t = −3.30, p =.001 |
ß= −0.09, t = −2.05, p =.042 |
ß= −0.05, t = −1.50, p =.14 |
ß= 1.13, t = 3.15, p =.001 |
ß=0.42, t = 1.36, p =.18 |
| Aß42 | ß=0.001, t = 3.49, p <.001 |
ß=0.001, t = 0.89, p = 0.37 |
ß= 0.001, t = 0.15, p =.88 |
ß= 0.001, t = 1.22, p =.22 |
ß= −0.001, t = −0.01, p =.99 |
ß=-0.001, t = −0.01, p =.99 |
| pTau | ß= 0.005, t = 0.84, p =.40 |
ß= −0.004, t = −1.03, p =.30 |
ß= −0.002, t = −0.63, p =.53 |
ß= −0.003, t = −1.04, p =.30 |
ß=0.01, t = 0.49, p =.63 |
ß=0.02, t = 0.82, p =.41 |
| Occipital | ||||||
| WML load | ß= −0.04, t = −0.46, p =.65 |
ß= −0.05, t = −0.75, p =.46 |
ß= −0.02, t = −0.38, p =.70 |
ß= −0.11, t = −2.35, p =.019 |
ß= 1.02, t = 1.83, p =.07 |
ß=0.75, t = 1.59, p =.11 |
| Aß42 | ß=0.001, t = 3.85, p <.001 |
ß=0.001, t = 1.63, p = 0.10 |
ß= 0.001, t = 0.69, p =.49 |
ß= 0.001, t = 1.16, p =.25 |
ß= −0.001, t = −0.58, p =.57 |
ß=-0.001, t = −0.03, p =.98 |
| pTau | ß= 0.005, t = 0.89, p =.37 |
ß= −0.004, t = −0.90, p =.36 |
ß= −0.002, t = −0.54, p =.59 |
ß= −0.003, t = −0.98, p =.33 |
ß=0.01, t = 0.36, p =.72 |
ß=0.02, t = 0.79, p =.43 |
Notes: Results that differ from Table 2 (total WML) results are shown in bold. Abbreviations: ADAS-13, Alzheimer’s Disease Assessment Scale-13; WML, White matter lesion.