FIGURE 3.

Murine daily activities are influenced by apolipoprotein E (APOE) genotype and running. A,D, Cumulative food consumed per gram for female (A, n = 9–11) and male (D, n = 9–12) mice across four dark cycles and three light cycles. B‐C, Running significantly increased food consumed during the dark cycle (B), but not the light cycle (C) in female mice. E‐F, APOE genotype and APOE genotype:running interaction affected food consumption in males during the dark cycle (E), but no effect was seen during the light cycle (F). G,J, General movement (cumulative ped meters) for female (G) and male (J) mice across four dark cycles and three light cycles. H‐I, APOE genotype, running, and APOE genotype:running interaction all significantly affected ped meters during the dark cycle (H) with running decreasing ped meters differently across the genotypes. Only APOE genotype was significant during light cycle (I) in female mice. K‐L, APOE genotye:Running interaction significantly affected ped meters in males, with APOE ε4/ε4 showing increased ped meters during the dark cycle (K), as well as the light cycle (L). There was also an APOE genotype effect (L). Solid lines indicate Run mice, dashed lines indicate Sed mice (A,D,G,J). Data presented as mean ± standard error of the mean, two‐way analysisof variance performed for APOE genotype (significant marked above “Sed” column, indicating an effect of APOE genotype), running (significance marked above “Run” column, indicating an effect of running), and APOE genotype:running interaction (significance marked in to the right of the graph). Bonferroni's multiple comparisons performed for within‐genotype running effects (significance marked in smaller stars directly to the right of the run column, within graph limits, in the color of the genotype). *P < .05, **P < .01, ***P < .001, ****P < .0001