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. 2022 Jun 29;23:174. doi: 10.1186/s12931-022-02038-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Association of circulating CC16 levels and categorical BMI in three populations. The values are shown as the least-square means, and the error bars depict the upper and lower 95% CI. Figures indicate fully adjusted associations between BMI values and circulatory CC16 levels (ng/mL). Model 1 (partially adjusted model): adjusted by age, sex, smoking status, and history of doctor-diagnosed asthma for population 1; adjusted by sex, age, smoking status for population 2; adjusted by age, sex, smoking status, and asthma severity for population 3; for the combination of populations 1, 2, and 3; adjusted by age, sex, and smoking status. Model 2 (fully adjusted model): adjusted for covariates in Model 1 and the CC16 A38G polymorphism (rs3741240)