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. 2022 Jun 29;23:174. doi: 10.1186/s12931-022-02038-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — BMI, circulatory CC16, and airway hyperresponsiveness in young healthy participants (Population 2). A The figure indicates the unadjusted associations between BMI and Log Dmin. B Mediation analyses were performed to estimate the direct and mediation effect of BMI on Log Dmin (airway hyperresponsiveness; AHR) mediated by circulatory CC16 in young healthy participants. Numbers in the parentheses indicate the estimates, 95% confidence intervals (in the parentheses), and p-values