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. 2022 Jun 29;22:713. doi: 10.1186/s12885-022-09810-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — Functional enrichment of PTTG1 transcriptional targets in BLCA tissue. Differentially expressed genes (DEGs) associated with CHEK2, OCIAD2, UBE2L3, and ZNF367 were identified from the TCGA-BLCA cohort study. The prospective biological functions of these PTTG1 targets were annotated. A. CHEK2-related DEGs were significantly enriched in the antibacterial humoral response. B. OCIAD2-related DEGs were significantly enriched in the complement activation (classical pathway). C. UBE2L3-related DEGs were significantly enriched in the phagocytosis and recognition. D. ZNF367-related DEGs were significantly enriched in the cell cycle pathway. BLCA, bladder carcinoma