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. 2022 Jun 29;22:713. doi: 10.1186/s12885-022-09810-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Potential association between PTTG1 and tumor microenvironment in bladder cancer tissue samples. The immune infiltration levels of immune and stromal cells of TCGA-BLCA patients were quantified by using the Microenvironment cell populations-counter algorithm. A The immune microenvironment and clinical phenotypes were compared in normal bladder tissues, PTTG1 low expression bladder cancer tissue samples, and PTTG1 high expression bladder cancer tissue samples. B Higher PTTG1 mRNA expression levels indicated higher natural killer, cytotoxic lymphocyte, and monocyte lineage cell infiltration levels, and indicated lower neutrophils and endothelial cell infiltration levels. C The immune score was significantly lower in low PTTG1 mRNA expression bladder cancer tissue samples than that in high PTTG1 mRNA expression bladder cancer tissue samples or normal bladder tissue samples. However, no difference was detected in the stromal score of low PTTG1 mRNA expression bladder cancer tissue samples than that in high PTTG1 mRNA expression bladder cancer tissue samples (P < 0.05). D A high stromal score predicted poor prognosis in bladder carcinoma patients. E The prognostic value of the immune score in bladder carcinoma was insignificant (P < 0.05). **, P < 0.01; ****, P < 0.0001