Table 4.
Prediction accuracy of the trans-ancestry T2D PRS in the Taiwan Biobank (TWB)
| Batch | Liability R2 | Covariates-adjusted AUC | OR per SD (95% CI) |
Top 2% PRS | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) |
P value | Sensitivity | Specificity | Adjusted PPV* | Adjusted NPV* | ||||
| Batch 1 | 15.1% | 0.70 |
2.19 (2.05, 2.33) |
4.62 (3.56, 5.99) |
7.47E−31 | 0.07 | 0.98 | 0.37 | 0.87 |
| Batch 2 | 12.9% | 0.68 |
2.01 (1.93, 2.10) |
4.60 (3.88, 5.45) |
1.80E−69 | 0.07 | 0.98 | 0.38 | 0.87 |
| Batch 3 | 15.3% | 0.70 |
2.16 (1.96, 2.38) |
4.35 (2.89, 6.53) |
1.43E−12 | 0.06 | 0.98 | 0.36 | 0.87 |
*Adjusted PPV and NPV are calculated using 13.7% for the Asian population