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. 2022 Jun 28;29:46. doi: 10.1186/s12929-022-00828-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Proximal tubular-specific XBP1 knockout mice exacerbate maladaptive repaired mechanisms following UIRI. a–d qPCR assessment of Kim-1, Adgre1, Tnf-α, and Il-6 mRNA expression levels. N = 6 for each group. Data are expressed as means ± SEM. ***P < 0.001 as compared with XBP1^fl/fl sham group, ^###P < 0.001 as compared with the indicated group. e Representative images of TUNEL and XBP1 co-stained renal sections in XBP1^fl/fl or XBP1^cKO mice after 15 days of UIRI surgery. Selected areas indicated TUNEL positive tubules. Scale bar: 50 μm