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. 2022 Apr 25;18(1):194–199. doi: 10.4103/1673-5374.343892

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NBP reverses iron-related protein expression in the substantia nigra in the rotenone-induced rat model of Parkinson’s disease.

(A) Western blot analysis of the expression of TfR, Ft-L, and Fpn1 in the substantia nigra in the rotenone-induced rat model of Parkinson’s disease with or without NBP treatment. (B–D) Quantitative results of TfR (B), Fpn1 (C), and Ft-L (D) expression. All data are shown as the mean ± SEM (n = 5–9 rats per group). **P < 0.01, ****P < 0.0001 (one-way analysis of variance followed by Tukey’s post hoc test). Fpn 1: Ferroportin 1; Ft-L: ferritin light chain; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; NBP: DL-3-n-butylphthalide; TfR: transferrin receptor.