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. 2022 Apr 25;18(1):189–193. doi: 10.4103/1673-5374.343888

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Copyright: © Neural Regeneration Research

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LTG ameliorated tau hyperphosphorylation in the brains of APP/PS1 mice.

(A) Hyperphosphorylated tau proteins at Ser214, Thr205, and Thr231 sites were detected by western blot assay. (B–D) Quantitation of hyperphosphorylated tau proteins at Ser214 (B), Thr205 (C), and Thr231 (D) sites. Data are expressed as means ± SD (n = 6). ***P < 0.001, vs. WT controls; ##P < 0.01, vs. APP/PS1 mice (one-way analysis of variance followed by Tukey’s post hoc test). APP/PS1: Amyloid precursor protein/presenilin 1; LTG: lamotrigine; P-tau: hyperphosphorylated tau; WT: wild-type.