Table 1.

Summary of small molecule agents for the treatment of non-glaucoma disease

Name	Target	Function	Disease/cell line	Publication
Arundic acid	S-100β	Activation of astrocytes	Stroke	Tateishi et al., 2002
BX795	TBK1	Induction of apoptosis	Squamous cell carcinoma	Bai et al., 2015
Compound 1	TBK1/IKKε	Enhancement of response to PD-1 blockade	Melanoma	Jenkins et al., 2018
GSK8612	TBK1	Inhibition of IFNB	THP-1	Thomson et al., 2019
Amlexanox	TBK1/IKKε	Inhibition of autophagy	Melanoma	Möller et al., 2020

This table summarizes the targets, functions, disease models, and literature linked to small molecule agents which may possess protective activity for retinal ganglion cells and are considered potential therapeutic drugs for non-glaucoma disease. IFNB: Interferon beta; IKKε: IkB kinase epsilon; PD-1: programmed death-1; S-100β: S100 protein β; TBK1: TANK-binding kinase 1; THP-1: human myeloid leukemia mononuclear cells.