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. 2022 Apr 25;18(1):111–112. doi: 10.4103/1673-5374.340404

Figure 1.

Figure 1

Diagram depicting the effect of RQC recruitment on resolving stalled translation and restoring cellular homeostasis, and how inadequate quality control of stalled translation and collided ribosomes may be linked to various hallmarks of neurodegenerative diseases, including proteostasis failure, mitochondrial dysfunction, and neuroinflammation.

CTE: C-terminal extension; cGAS-STING: the cyclic GMP-AMP synthase-stimulator of interferon genes; RQC: ribosome-associated quality control; UTR: untranslated regions.