FIG 4.
AZD6389 provides S. aureus strain coverage in the diabetic polymicrobial wound. Skin lesion size of mice (n = 10) inoculated with S. pyogenes (10 CFU)/P. aeruginosa (1.0 × 105 CFU) and various S. aureus wound isolates (1.0 × 106 CFU). AZD6389 (15 mg/kg each MAb) or c-IgG (15 mg/kg) was administered i.p 8 h later, and then 7 days later. Skin lesion sizes were measured at indicated days and represented as mean values ± standard errors mean (error bars). Statistical analysis between c-IgG and AZD6389 group was determined for each strain using a Vardi’s AUC test (two sample tests for growth under the curve dependent right censoring), and considered statistically different (P < 0.05) as indicated with a (*).