TABLE 1.

Performance of DPP Syphilis Screen & Confirm with visual operator inspection and microreader analysis (cutoff of 9.0) against reference comparator tests

Assay and detection methoda	No. of samples with:		Agreement (95% CI) (%)	Sensitivity (95% CI) (%)	Specificity (95% CI) (%)	Kappa coefficient (95% CI)
	True-positive results	True-negative results
Chembio treponemal component	n = 304	n = 79
Operator reading	261	79	88.7 (85.6–91.9)	85.9 (81.4–89.6)	100.0 (95.4–100.0)	0.71 (0.63–0.79)
Microreader	253	79	86.6 (83.2–90.1)	83.2 (78.5–87.2)	100.0 (95.4–100.0)	0.67 (0.59–0.75)
Chembio nontreponemal component	n = 242	n = 141
Operator reading	167	125	76.2 (71.9–80.5)	69.0 (62.8–74.8)	88.7 (82.2–93.4)	0.53 (0.44–0.61)
Microreader	159	126	74.4 (70.0–78.8)	65.7 (59.4–71.7)	89.4 (83.1–93.9)	0.50 (0.41–0.58)

^aReference tests were the TPPA test for treponemal antibodies and the RPR test for nontreponemal antibodies.