TABLE 2.

Performance of FilmArray Pneumonia Panel plus (FilmArray PP) in nasopharyngeal (NP) swabs for detection of S. pneumoniae, H. influenzae, and M. catarrhalis in adults with community-acquired respiratory tract infections (n = 118 patients) compared to various reference standards: FilmArray PP on a good-quality lower respiratory tract (LRT) sample with a positive cutoff value of >10⁴ copies/mL or with the standard microbiology results (lower respiratory tract sample culture, hemocultures, and S. pneumoniae urinary antigen)^a

Target organism	Reference standard	No. of positive samples		PPA	NPA	OPA	LR+	LR−	PPV	NPV
		NP	Reference standard
S. pneumoniae	LRT PCR FilmArray PP	11	19	0.58	1	0.93	Infinite	0.42	1	0.93
	Standard microbiology	11	12	0.58	0.96	0.92	15.46	0.43	0.64	0.95
H. influenzae	LRT PCR FilmArray PP	27	44	0.61	1	0.86	Infinite	0.39	1	0.81
	Standard microbiology	27	19	0.74	0.87	0.85	5.61	0.3	0.52	0.95
M. catarrhalis	LRT PCR FilmArray PP	9	14	0.57	0.99	0.94	59.43	0.43	0.89	0.94
	Standard microbiology	9	0		0.92	0.92			0	1

^aPositive percent agreement (PPA), negative percent agreement (NPA), overall percent agreement (OPA), positive likelihood ratio (LR+), negative likelihood ratio (LR−), positive predictive value (PPV), negative predictive value (NPV).