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. 2022 Apr 15;146(1):21–35. doi: 10.1161/CIRCULATIONAHA.121.056805

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Disease associations of lipid class-specific FA abundances by FA carbon chain length and number of unsaturated bonds. P values from models adjusted for age (as underlying time variable), sex, waist circumference, height, leisure time physical activity, smoking status, alcohol intake, highest achieved education level, fasting status at blood draw, total energy intake, blood pressure (systolic and diastolic), blood lipids (total cholesterol, high-density lipoprotein cholesterol, and standard clinical triacylglycerols), antihypertensive medication, lipid-lowering medication, acetylsalicylic acid medication, and respective class sum. Models for CVD further adjusted for antidiabetic medication and proportion glycohemoglobin. CE indicates cholesteryl esters; Cer, ceramides; CVD, cardiovascular disease; DG, diacylglycerols; dhCer, dihydroceramides; FFA, free fatty acids; HexCer, hexosylceramides; LacCer, lactosylceramides; LPC, lysophosphatidylcholines; LPE, lysophosphatidylethanolamines; MG, monoacylglycerols; PC, phosphatidylcholines; PE, phosphatidylethanolamines; PEO, phosphatidylethanolamine ether; PEP, phosphatidylethanolamine plasmalogen; PI, phosphatidylinositol; SM, sphingomyelins; and TG, triacylglycerols.