FIG 1.
Summary and timeline of SARS-CoV-2 RT-PCR positivity, serology results, treatments, and key clinical events for patient A (A) and patient B (B). SARS-CoV-2 RT-PCR E gene and N gene CT values were obtained during routine diagnostic testing of nasopharyngeal swab samples using the Cepheid Xpert Xpress SARS-CoV-2 assay. The TaqPath Combo kit (Thermo Fisher Scientific) additionally detected S gene and ORF1ab targets in both patients’ samples (circles, Xpert Xpress SARS-CoV-2 assay; squares, TaqPath Combo kit). Serology tests for IgG against the SARS-CoV-2 RBD and N protein were performed during routine diagnostic testing using the chemiluminescent microparticle immunoassay (CMIA) on the Architect i2000SR system (Abbott Laboratories). Hydrocortisone (patient A, days 50 to 55) and dexamethasone (patient B, days 2 to 11) dosages were converted to prednisolone-equivalent doses for ease of visualization. Data used to generate this figure are available in Supplemental tables 1A and 1B.