TABLE 1.
Activity of omadacycline and comparator agents against clinical carbapenem-nonsusceptible Acinetobacter baumannii isolates (n = 41)a
| MIC (mg/L) |
Susceptibility (%) |
|||||
|---|---|---|---|---|---|---|
| Agent | 50% | 90% | Range | S | I | R |
| Amikacin | 128 | >256 | 2 to >256 | 12.2 | 24.4 | 63.4 |
| Meropenem | ≥256 | ≥256 | 4 to ≥256 | 0 | 2.4 | 97.6 |
| Minocycline | 16 | 16 | 0.25 to 32 | 29.3 | 19.5 | 51.2 |
| Omadacycline | 4 | 8 | 1 to 16 | NC | NC | NC |
| Polymyxin B | 0.5 | 0.5 | 0.125 to ≥128 | NC | 95.1 | 4.9 |
| Rifampin | 16 | 64 | 4 to >256 | NC | NC | NC |
| Sulbactam | 32 | 128 | 2 to 128 | 2.4 | 0 | 97.6 |
| Tigecycline | 4 | 8 | 1 to 16 | NC | NC | NC |
a
S, susceptible; I, intermediate; R, resistant; NC, no applicable interpretive criteria available.