TABLE 3.

Representative doses and fC_max values simulated for each agent in time-kill experiments

Agent	Dosea	Cmax (mg/L)	Protein binding (%)	fCmax (mg/L)	Reference
Amikacin	15 mg/kg i.v. over 1 h	60	7.5	55.5	(54)
Meropenem	2 g i.v. over 3 h	40.9	2	40	(55)
Minocycline	100 mg i.v. over 1 h	0.99	76	0.24	(56, 57)
Omadacycline	100 mg i.v. over 30 min	1.51	21	1.21	(14)
Polymyxin B	1.5 mg/kg i.v. over 1 h	6.21	58	2.61	(58)
Rifampin	300 mg i.v. over 30 min	8.90	80	1.78	(59)
Sulbactam	1 g i.v. over 30 min	98	38	60.8	(60)
Tigecycline	50 mg i.v. over 30 min	0.38	80	0.08	(61)

^aSingle doses.